se debe instalar el modulo https://www.drupal.org/project/twig_tweak
{% set thumbnail = node.field_image %}
<div class='col-md-2 col-xs-6 center mb-lg'>
<img src='{{ file_url(thumbnail.entity.uri.value|image_style(medida_165x165_)) }}'class='img-responsive' alt=''>
<h5 class='mt-sm mb-none'>{{ label }}</h5>
<p class='mb-none'>prueba</p>
</div><img src="{{ node.field_image | file_uri | file_url }}" class="card-img-top" height="230" style="border-top: 4px solid #F26334;">